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High Intensity Focused Ultrasound (20 MHz) and Cryotherapy as Therapeutic Options for Granuloma Annulare and Other Inflammatory Skin Conditions.

Dermatol Ther (Heidelb) 2024;1-22.   Calik, J., Zawada, T., Sauer, N. et al.   https://link.springer.com/article/10.1007/s13555-024-01163-7?utm_source=rct_congratemailt&utm_medium=email&utm_campaign=oa_20240504&utm_content=10.1007%2Fs13555-024-01163-7#Abs1 Abstract:  Introduction:  In dermatology, inflammatory skin conditions impose a substantial burden worldwide, with existing therapies showing limited efficacy and side effects. This report aims to compare a novel immunological activation induced by hyperthermic 20 MHz high intensity focused ultrasound (HIFU) with conventional […]

Analytical modeling of harmonically driven focused acoustic sources with experimental verification. 

Applied Acoustics, 2024;221,1-19: T. Zawada, T. Bove.  https://www.sciencedirect.com/science/article/abs/pii/S0003682X24001403 Abstract:  Recently, a high intensity focused ultrasound (HIFU) is drawing a lot of attention from medical and non-medical fields due to its potential for extreme high pressure levels as well as ultra high spatial resolution. At the heart of every HIFU system is a focused ultrasound transducer, […]

High‐intensity focused ultrasound: safety and efficacy of a novel treatment modality for neurofibromatosis type 1 cutaneous neurofibroma.

JEADV Clin Pract. 2024;1–12:  Peltonen S, Serup J, Tang M, Gillstedt M, Kantere D, Neittaanmäki N,et al. https://onlinelibrary.wiley.com/doi/10.1002/jvc2.398 Abstract:  Background:  High-intensity focused ultrasound (HIFU) is widely used in the treatment of deep tumours, but clinical trials on skin tumours are not yet available. Neurofibromatosis Type I (NF1) is among the most common single-gene inherited conditions […]

Healing Process after High-Intensity Focused Ultrasound Treatment of Benign Skin Lesions: Dermoscopic Analysis and Treatment Guidelines.

Journal of Clinical Medicine. 2024;13(4):931:   Calik J, Zawada T, Bove T, Dzięgiel P, Pogorzelska-Antkowiak A, Mackiewicz J, Woźniak B, Sauer N.  https://www.mdpi.com/2077-0383/13/4/931 Abstract:  Background:   High-Intensity Focused Ultrasound (HIFU) has emerged as a precise and non-invasive modality for tissue ablation and healing. This study presents a detailed dermoscopic analysis of skin healing post-High-Intensity Focused Ultrasound (HIFU) […]

Head-to-Head Comparison of Acoustic Properties of Lead-Free and PZT-Based HIFU Transducers Operating at 12 MHz.  

IEEE Trans Ultrason Ferroelectr Freq Control. 2024 Jan;71(1):16-26: Zawada T, Bove T, Lou-Moller R, Ringgaard E.  https://ieeexplore.ieee.org/document/10068226 Abstract:  A direct comparison of performance and acoustic properties of high-intensity focused ultrasonic transducers utilizing lead-free (sodium bismuth titanate—NBT) and lead-based (lead zirconate titanate—PZT) piezoceramics is discussed. All transducers operate at 12 MHz at third harmonic frequency, having […]

Treatment of Cutaneous Neurofibromas in Patients with Neurofibromatosis Type 1.

Case Rep Dermatol 2023;15(1):194–201:   Wozniak B, Bove T, Zawada T, Calik J.  https://karger.com/cde/article/15/1/194/867389/Treatment-of-Cutaneous-Neurofibromas-in-Patients Abstract:  Neurofibromatosis type 1 is a genetic disorder impacting approximately 2.5 million people worldwide, often leading to development of numerous benign yet disfiguring cutaneous neurofibromas (cNF). Removal of cNF is limited to excision or laser ablation with common post-operation complications and scarring. […]

High-Frequency (20 MHz) Focused Ultrasound: A Novel Method for Noninvasive Tattoo Removal.

Curr Probl Dermatol. 2022;56:268-280:  Bove T, Zawada T, Serup J, Jessen A, Poli M.  https://karger.com/books/book/5533/chapter-abstract/12981091/High-Frequency-20-MHz-Focused-Ultrasound-A-Novel?redirectedFrom=fulltext Abstract:  Alternatives or complements to laser tattoo removal are needed. Laser removal requires 8-12 session and can easily take more than a year. Some colors cannot be removed, and scars may appear. Applied to allergic reactions in red tattoos, lasers […]

Acoustic field of strongly focused HIFU transducer operating at 20 MHz – comparison of public domain numerical simulators with experimental observations.

2022 IEEE International Ultrasonics Symposium (IUS), Venice, Italy, 2022;1-4:  T. Zawada and T. Bove,  https://ieeexplore.ieee.org/document/9958122 Abstract:  Recently, a new modality for dermatological intervention involving therapeutic ultrasound with integrated optical imaging has been demonstrated for treatments of actinic keratosis, basal cell carcinoma, vascular malformations etc. Such modality requires very confined focal zones which are typically generated […]

Treatment of Condylomata Acuminata Using a New Non-Vapor-Generating Focused Ultrasound Method following Imiquimod 5% Cream. 

Case Rep Dermatol 2022:275-282:  Calik J, Zawada T, Bove T  https://karger.com/cde/article/14/3/275/821812/Treatment-of-Condylomata-Acuminata-Using-a-New-Non Abstract:  Condylomata acuminata is the most common sexually transmitted disease in the world. Physical treatments include excision, cryotherapy, electrocautery and ablative CO2, and Nd:YAG laser ablation, while topical treatments include imiquimod immunotherapy and antimitotic podophyllotoxin or sinecatechins. Efficacies of all methods are low, and […]